Saturday, October 27, 2012

Laser Spotlight Reveals Machine 'Climbing' DNA

Imaging the molecular machine MukBEF using flourescent tags attached to its component parts. (Credit: Image courtesy of University of Oxford)
ScienceDaily (Oct. 26, 2012) — New imaging technology has revealed how the molecular machines that remodel genetic material inside cells 'grab onto' DNA like a rock climber looking for a handhold.

The experiments, reported in this week's Science, use laser light to generate very bright patches close to single cells. When coupled with fluorescent tags this 'spotlight' makes it possible to image the inner workings of cells fast enough to see how the molecular machines inside change size, shape, and composition in the presence of DNA.
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Sources: University of Oxford, .


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